Sleep deprivation has significant adverse effects on memory, impacting both the encoding and retrieval processes. Research indicates that sleep deprivation before learning impairs the ability to encode new information, leading to poorer memory performance. This is supported by meta-analytic data showing a substantial effect size (Hedges' g = 0.621) for memory impairment when sleep deprivation occurs before learning. [1] Sleep deprivation after learning also disrupts memory consolidation, particularly affecting hippocampal-dependent memory processes. The effect size for memory impairment in this context is smaller (Hedges' g = 0.277) but still significant, with immediate testing showing more pronounced deficits compared to delayed testing. [1] At the molecular level, sleep deprivation alters gene transcription and protein synthesis in the brain, particularly in the hippocampus, which is crucial for memory formation and consolidation.[2] This disruption can lead to changes in dendritic structure and synaptic plasticity, further impairing memory processes. Additionally, sleep deprivation can cause temporary amnesia-like deficits, affecting not only memory but also cognitive processes that rely on memory, such as decision-making.[3] This suggests that the impact of sleep deprivation on memory is multifaceted, involving both direct effects on memory encoding and consolidation, as well as broader cognitive impairments. In summary, sleep deprivation negatively affects memory by impairing encoding, disrupting consolidation, and altering molecular processes essential for memory function. These effects underscore the importance of adequate sleep for optimal cognitive performance and memory retention
